Effect of nutritional state on IVIM parameters measured with multiple b value diffusion MRI

1) Kwee TC, et al. JMRI 2008;28:1141-1148 2) Hollingsworth KG, et al. NMR Biomed 2006;19:231-235 3) Rosenkrantz A, et. al. Proc. ISMRM;2009;17:2065 4) Sadek AG et al. JMRI 1996;6(1):90-3. 5) LeBihan D, Radiology 1988;168:497-505, 1988 6) Haber E, et al. Lecture Notes in Comp. Sci. 2005:561-572 Figure 2: Relative changes in the diffusion components after a liquid meal. Notice perfusion fraction is consistently elevated after the meal while the other components are decreased. ADCTotal = the apparent diffusion coefficient including all b values measures, ADCHigh = the apparent diffusion coefficient excluding the low B values (less perfusion sensitive), D = the true diffusion coefficient, PF = the perfusion fraction. Figure 1: Screenshot of computed images. The ROI was drawn to avoid large blood vessels. Dslow = the slow components of the diffusion fraction, Dfast = the fast components of the diffusion fraction (affected by gross bloodflow), ADC = apparent diffusion coefficient, pf = perfusion fraction. Effect of nutritional state on IVIM parameters measured with multiple b value diffusion MRI